ea0038p240 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015
Lerner Avi
, Kewada Drashti
, Okolo Anthony
, Hardy Kate
, Franks Stephan
Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is associated with an adverse metabolic profile including insulin resistance and dyslipidaemia. Hyperandrogenism is the hallmark of PCOS and obesity increases androgen synthesis, partly due to accompanying hyperinsulinemia but also as a result of adipokines affecting ovarian steroidogenesis (Comim et al., 2013, PLoS ONE 8(11). Adipokines are factors secreted by adipose tissue and while a clear link betwe...